These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Intermittent hypoxia promotes the expressions of rat hippocampal neuronal hypoxia-inducible factor-1 and survivin].
    Author: Wang L, Zhang P, Wang H, Yu J, Zhang M, Han X, Li L, Liu C.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2015 Mar; 31(3):338-41. PubMed ID: 25744839.
    Abstract:
    OBJECTIVE: To establish an intermittent hypoxia (IH) animal model by simulating the features of obstructive sleep apnea-hypopnea syndrome and observe the expressions of hypoxia-inducible factor-1 (HIF-1) and survivin and the occurrence of apoptosis in the hippocampal CA1 neuron of rats with early IH. METHODS: Male Wistar rats (n=72) were randomly divided into control group and IH group. In control group, rats were given compressed air and in IH group, rats were exposed to 50 mL/L IH for 7 hours a day, lasting 3, 7, 14 and 21 days, respectively. The expressions of HIF-1 and survivin in hippocampal CA1 were detected by immunohistochemistry and the neuronal apoptosis index was calculated by TUNEL. RESULTS: Compared with control group, apoptosis index in the third day of 5% IH group had no significant difference, while apoptosis index in IH 7-, 14- and 21-day groups were significantly higher than that in control group, and on the 21st day it reached a peak. The expressions of HIF-1 and survivin protein in 5% IH group significantly increased as compared with control group at each time point, and they peaked on the 14th day, then decreased gradually. There was a positive relationship between the expressions of HIF-1 and survivin. CONCLUSION: Early IH can induce HIF-1 and survivin protein expressions in rat hippocampal CA1, and their expressions may play an important role in the regulation of neuronal apoptosis.
    [Abstract] [Full Text] [Related] [New Search]