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  • Title: Astemizole in perennial allergic rhinitis with seasonal exacerbations: a placebo-controlled double-blind study.
    Author: Tanay A, Neuman I.
    Journal: Ann Allergy; 1989 Dec; 63(6 Pt 1):493-4. PubMed ID: 2574549.
    Abstract:
    Astemizole is a nonsedative H1-antagonist. It was used in a randomized double-blind, placebo-controlled in-season trial to assess its efficacy in patients with perennial allergic rhinitis showing seasonal exacerbations. By the last (6th) week of the study, the mean overall symptomatology, as rated by a global composite score, was significantly mitigated in the astemizole-treated group (18 patients) compared with their first week's global composite score (P less than .01). No such improvement was observed in the placebo-treated group (18 patients). Side effects were not appreciable throughout this short-term study. We conclude that astemizole is effective in the treatment of patients with perennial allergic rhinitis showing seasonal enhancement of symptoms.
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