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  • Title: Synthesis of new nebularine analogues and their inhibitory activity against adenosine deaminase.
    Author: Lougiakis N, Marakos P, Pouli N, Fragopoulou E, Tenta R.
    Journal: Chem Pharm Bull (Tokyo); 2015; 63(2):134-42. PubMed ID: 25748785.
    Abstract:
    A number of new 2,6-disubstituted-1-deazanebularine analogues as well as two structurally related pyrazole-fused tricyclic nucleosides were prepared. Their synthesis was carried out by the conversion of 6-amino-2-picoline to a suitable 1-deazapurine, followed by a Vorbrüggen type glycosylation and subsequent elaboration of the condensed pyrazole ring. The synthesized nebularine analogues proved to be weak adenosine deaminase inhibitors.
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