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  • Title: Central temperature effects of the transmitter amino acids.
    Author: Yakimova K, Ovtcharov R.
    Journal: Acta Physiol Pharmacol Bulg; 1989; 15(3):50-4. PubMed ID: 2574933.
    Abstract:
    Experiments were carried out to determine the temperature changes induced by the transmitter amino acids gamma-aminobutyric acid (GABA), taurine and glycine (representatives of the inhibitor class of amino acids), and of L-glutamic acid and L-aspartic acid (representatives of the excitatory functional class of amino acids). The amino acids were introduced directly into the preoptic anterial part of the hypothalamus (PO/AH). The experiments were made on male Wistar rats into which cannules were implanted in advance in PO/AH using a stereotaxic apparatus and coordinates of administration after König and Klippel. At ambient temperature of 22 degrees C GABA and taurine are found to cause a dose-dependent hypothermal response, L-aspartic acid and L-glutamic acid lead to dose-dependent hyperthermia, while glycine does not change the body temperature.
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