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  • Title: Effects of fenoldopam on alpha-methyl-p-tyrosine-stimulated prolactin secretion in conscious rats.
    Author: Schoors DF, Dupont AG.
    Journal: Eur J Pharmacol; 1989 Nov 28; 173(1):109-12. PubMed ID: 2575038.
    Abstract:
    Pituitary dopamine D-2 receptors participate in the regulation of prolactin (PRL) release. No dopamine D-1 receptors have so far been identified in the pituitary gland. The present study was designed to assess the effects of fenoldopam, a selective dopamine D-1 receptor agonist, on alpha-methyl-p-tyrosine-stimulated PRL release. Fenoldopam dose dependently reduced the alpha-methyl-p-tyrosine-stimulated PRL secretion. This inhibitory effect of fenoldopam was abolished after pretreatment with SCH 23390, a specific dopamine D-1 receptor antagonist, suggesting the involvement of a dopamine D-1 receptor in PRL secretion.
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