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  • Title: Evaluation of human and simian immunodeficiency virus plaque and neutralization assays.
    Author: McKeating JA, McKnight A, McIntosh K, Clapham PR, Mulder C, Weiss RA.
    Journal: J Gen Virol; 1989 Dec; 70 ( Pt 12)():3327-33. PubMed ID: 2575137.
    Abstract:
    A number of CD4+ T cell lines were compared for their ability to act as target cells for human immunodeficiency virus (HIV) infection in syncytium- and plaque-forming assays. MT-4 and C8166 cells were the most sensitive indicator cells for HIV- and simian immunodeficiency virus (SIV)-induced cytopathic effects, and gave rise to macroscopic (MT-4) and microscopic (C8166) plaques. The MT-4 plaque assay was evaluated for the measurement of HIV- and SIV-neutralizing antibodies.
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