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  • Title: Structural organization of the dynein-dynactin complex bound to microtubules.
    Author: Chowdhury S, Ketcham SA, Schroer TA, Lander GC.
    Journal: Nat Struct Mol Biol; 2015 Apr; 22(4):345-7. PubMed ID: 25751425.
    Abstract:
    Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein-dynactin complex is unknown. Using electron microscopy, we determined the organization of native bovine dynein, dynactin and the dynein-dynactin-microtubule quaternary complex. In the microtubule-bound complex, the dynein motor domains are positioned for processive unidirectional movement, and the cargo-binding domains of both dynein and dynactin are accessible.
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