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  • Title: A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri.
    Author: Suárez AI, Mancebo M, Delle Monache F, Tirri MM, Sojo F, Arvelo F, Tillett S.
    Journal: Nat Prod Res; 2016; 30(4):399-405. PubMed ID: 25752927.
    Abstract:
    A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using (1)H and (13)C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.
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