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  • Title: Sequential management of post-myocardial infarction ventricular septal defects.
    Author: Trivedi KR, Aldebert P, Riberi A, Mancini J, Levy G, Macia JC, Quilicci J, Habib G, Fraisse A.
    Journal: Arch Cardiovasc Dis; 2015 May; 108(5):321-30. PubMed ID: 25754906.
    Abstract:
    BACKGROUND: Ventricular septal defect (VSD) after acute myocardial infarction is a catastrophic event. AIMS: We describe our multicentre experience of a defect closure strategy that combined surgery and transcatheter closure. METHODS: Data were obtained by retrospective chart review. RESULTS: Twenty patients (mean age, 67 years) from three centres were studied. Median time from myocardial infarction to VSD was 6 (range, 3-9) days. Acute cardiogenic shock occurred in 12 (60%) patients. Median defect diameter by echocardiography was 18 (range, 12-28) mm. Median time to first surgical or percutaneous closure was 18 (range, 4-96) days. Twenty-seven procedures were performed in the 20 patients. Surgical closure was undertaken in 14 patients and contraindicated in eight, six of whom underwent percutaneous closure; the other two, after reconsideration, proceeded to surgical closure. No procedural complications occurred with percutaneous closure. Percutaneous closure patients were older than surgical patients (75 vs. 64 years; P=0.01) and had a higher mean logistic EuroSCORE (87% vs. 67%; P=0.02). Rates of residual shunt and mortality did not differ between surgical and percutaneous patients (P=0.12 and 0.3, respectively). Those who underwent early VSD closure (<21 days after myocardial infarction) had higher rates of residual shunt (P=0.09) and mortality (P=0.01), irrespective of closure strategy. The mortality rate was also higher after early percutaneous closure (P=0.001), but not after early surgery. Finally, predicted mortality (logistic EuroSCORE) was higher than hospital mortality (≤30 days) in our patient population (75% vs. 30%; P=0.01). CONCLUSION: Vigorous pursuit of closure of post-myocardial infarction VSD with a sequential surgical and/or percutaneous approach is recommended for improved outcomes.
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