These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The alpha 2-adrenoceptor antagonists idazoxan and yohimbine can unmask the postsynaptic dopamine agonist effects of B-HT 920.
    Author: Meltzer LT, Wiley JN, Heffner TG.
    Journal: Eur J Pharmacol; 1989 Oct 24; 170(1-2):105-7. PubMed ID: 2575523.
    Abstract:
    Administration of B-HT 920 alone produced weak stereotypy in a small percentage (4-8%) of rats. In contrast, after combined administration of idazoxane and B-HT 920, stereotyped behaviors (sniffing and licking) were consistently produced in all rats. The appearance of stereotypy after combined treatment with yohimbine and B-HT 920 was inversely related to the dose of yohimbine. These data suggest that the alpha 2-adrenoceptor agonist effects of B-HT 920 can mask it's postsynaptic dopamine agonist effects.
    [Abstract] [Full Text] [Related] [New Search]