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  • Title: Hormonal and paracrine regulation of gamma-glutamyl transpeptidase in rat Sertoli cells.
    Author: Schteingart HF, Rivarola MA, Cigorraga SB.
    Journal: Mol Cell Endocrinol; 1989 Nov; 67(1):73-80. PubMed ID: 2575549.
    Abstract:
    The effects of follicle-stimulating hormone (FSH) and testosterone on Sertoli cell gamma-glutamyl transpeptidase (gamma-GTP) activity have been studied in vitro. Addition of FSH to Sertoli cell cultures for 5 days induced stimulation of gamma-GTP activity. No testosterone effect was observed alone or in combination with different doses of FSH. Time course studies for a supramaximal dose of FSH showed that enzyme induction could be achieved after a 48 h stimulation. Furthermore, a gradual stimulation of gamma-GTP activity in response to increasing numbers of germinal cells (GC) added in coculture, was observed. Stimulation was also demonstrated with germinal cell-conditioned medium (GCCM). Stimulatory effects of GC and GCCM were additive with those of FSH, suggesting that different mechanisms were involved.
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