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  • Title: [The concept of suppressor genes in the molecular biology of central nervous system tumors].
    Author: el-Azouzi M, Black PM.
    Journal: Neurochirurgie; 1989; 35(4):201-8. PubMed ID: 2575713.
    Abstract:
    Recently, major advances have resulted from the application of molecular biology to the understanding of central nervous system neoplasia. Schematically, two fundamental mechanisms of tumorigenesis have been described: the activation of oncogenes, and the inactivation of so called recessive "tumor suppressor" genes or "anti-oncogenes". The present report deals with the second mechanism. We discuss its basic concept and techniques, and illustrate it by specifc examples of recent work on brain tumors. The goal of this review is to familiarize Neurosurgeons with the terminology and techniques in this field. Molecular genetics suggest that cancer is a molecular disease which involves regulator genes. These play a major role in growth control, differentiation, and physiology. In the near future molecular biology may identify the structure of proteins coded by suppressor genes, possibly allowing a better tumor classification creating a new "genetic therapy", based on a better comprehension of the role of these genes in dividing and differentiating cells.
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