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  • Title: Severe clinical manifestations of primary HIV infection.
    Author: Tindall B, Hing M, Edwards P, Barnes T, Mackie A, Cooper DA.
    Journal: AIDS; 1989 Nov; 3(11):747-9. PubMed ID: 2575913.
    Abstract:
    Three cases of oesophageal candidiasis in association with primary HIV infection are described. In each case the candidiasis was associated with a decreased number of circulating CD4+ cells and responded well to treatment with ketoconazole. Clinicians should be aware that severe opportunistic infections may develop during this stage of infection, presumably as a result of transient immunodeficiency. We argue that the definition of primary HIV infection should be extended to include severe opportunistic infections and neurologic presentations.
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