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  • Title: Dopamine D-1 and D-2 receptor agonists and antagonists and neuropeptide-induced excessive grooming.
    Author: Van Wimersma Greidanus TB, Maigret C, Torn M, Ronner E, Van der Kracht S, Van der Wee NJ, Versteeg DH.
    Journal: Eur J Pharmacol; 1989 Dec 07; 173(2-3):227-31. PubMed ID: 2576230.
    Abstract:
    The administration of the dopamine D-1 receptor antagonist, SCH 23390, but not of the dopamine D-2 receptor antagonist, sulpiride, suppressed the excessive grooming induced by a new environment or by various neuropeptides. In addition, administration of the dopamine D-1 agonist, SK & F 38393, induced excessive grooming but that of the dopamine D-2 agonist, quinpirole, did not. It is suggested that dopamine D-1 rather than D-2 receptor stimulation is an important mechanism underlying novelty-induced as well as neuropeptide-induced excessive grooming.
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