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  • Title: [Anti H2 receptors and perforated peptic ulcer. Review of 442 cases].
    Author: Mastroianni V, Calgaro M, Manfredi S, Manzini R, Bevilacqua S.
    Journal: Minerva Chir; 1989 Nov 15; 44(21):2259-62. PubMed ID: 2576300.
    Abstract:
    H2 blockers have accelerated the reduction in elective peptic ulcer surgery but appear to have had no equivalent effect on the incidence of perforated ulcer success. A 13 year (1975-1987) review of perforated peptic ulcer is presented. The mean annual number of operations for perforation fell from 8.21% to 4.93% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged. A significant reduction was found in mean annual rates for perforated duodenal ulcer from 6.86% to 3.82% after 1980, while the number of operations for perforated gastric ulcer in this period was almost unchanged.
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