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  • Title: Different effects of ANP and nitroprusside on cyclic GMP extrusion of isolated aorta.
    Author: Stasch JP, Kazda S, Neuser D.
    Journal: Eur J Pharmacol; 1989 Dec 19; 174(2-3):279-82. PubMed ID: 2576534.
    Abstract:
    Atrial natriuretic peptide (ANP) and sodium nitroprusside have potent vasodilator effects on the noradrenaline-precontracted isolated rabbit aorta. A distinct elevation of cyclic GMP in the aortic tissue was observed after both vasodilators. In contrast to sodium nitroprusside, ANP-(5-28) induced a dose-dependent cyclic GMP extrusion from the tissue into the medium. Thus, release of cyclic GMP appears to be specific for activation of particulate guanylate cyclase and provides a mechanism in addition to synthesis and degradation by which the cells can regulate their internal concentrations of cyclic GMP.
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