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  • Title: Enhancement of plaque formation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) by subinhibitory dose of acyclovir (ACV).
    Author: Shiraki K, Miyaki C, Namazue J, Yamanishi K, Takahashi M.
    Journal: Acta Virol; 1989 Dec; 33(6):565-8. PubMed ID: 2576598.
    Abstract:
    Acyclovir (9-/2-hydroxyethoxymethyl/guanine) enhanced the plaque formation of HSV and VZV at subinhibitory dose and inhibited at higher concentration but not in thymidine kinase deficient viruses. The enhancement was neutralized by thymidine. Induction of viral thymidine kinase activity was not affected with ACV. These results suggest that the enhancement may be mediated by viral thymidine kinase.
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