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  • Title: Linkage of the Dao-1 gene for D-amino-acid oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5.
    Author: Konno R, Niwa A, Yasumura Y.
    Journal: Jpn J Genet; 1989 Oct; 64(5):341-5. PubMed ID: 2576634.
    Abstract:
    Linkage of the Dao-1 gene controlling D-amino-acid oxidase to the Pgm-1 gene controlling phosphoglucomutase-1 on the mouse chromosome 5 was examined. Mutant ddY/DAO- mice carrying a null Dao-1c allele had a Pgm-1a allele. Mutant mice were crossed to C3H/HeN and NZB/Kl mice carrying the Dao-1+ and Pgm-1b alleles. The hybrid F1 mice were backcrossed to the ddY/DAO- and their progeny were examined for alleles for D-amino-acid oxidase and phosphoglucomutase-1. In both backcrosses, the progeny with recombinant-type combinations of the alleles were significantly less than the progeny with the parental-type combinations, indicating the linkage of the Dao-1 and Pgm-1 genes. The recombination frequency between these loci was estimated to be 19.8 +/- 4.0%.
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