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  • Title: Glutamine assimilation pathways in Neurospora crassa growing on glutamine as sole nitrogen and carbon source.
    Author: Calderón J, Mora J.
    Journal: J Gen Microbiol; 1989 Oct; 135(10):2699-707. PubMed ID: 2576659.
    Abstract:
    Neurospora crassa wild-type is almost unable to grow on glutamine as sole nitrogen and carbon source but a GDH-; GS +/- double mutant strain, lacking NADP-dependent glutamate dehydrogenase and partially lacking glutamine synthetase did grow. Under these conditions, the double mutant had a higher chemical energy content than the wild-type. Enzyme assays and labelling experiments with glutamine indicated that in the double mutant glutamine was degraded to ammonium and to carbon skeletons by glutamate synthase, the catabolic (NADH-dependent) glutamate dehydrogenase and the glutamine transaminase-omega-amidase pathway.
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