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  • Title: Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina.
    Author: Iwasaki A, Ohno O, Sumimoto S, Matsubara T, Shimada S, Sato T, Suenaga K.
    Journal: J Nat Prod; 2015 Apr 24; 78(4):901-8. PubMed ID: 25768725.
    Abstract:
    Mebamamides A and B, new lipopeptides with four d-amino acid residues and a 3,8-dihydroxy-9-methyldecanoic acid residue, were isolated from the green alga Derbesia marina. Their gross structures were elucidated by spectroscopic and ESI-ITMS analyses. The absolute configurations except for the two leucines were revealed based on chiral-phase HPLC analyses of the acid hydrolysate and a modified Mosher's method. A distinction between D-Leu and L-Leu in the sequence was established by the application of a dansyl-Edman method to the partial acid hydrolysate. Mebamamide A did not exhibit any growth inhibitory activity against HeLa and HL60 cells at 10 μM, and mebamamide B did not exhibit any growth inhibitory activity against those cells at 100 μM. Additionally, it was suggested that mebamamide B induced the differentiation of HL60 cells into macrophage-like cells at 100 μM.
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