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  • Title: P-fimbriae vaccines. I. Cross reactive antibodies to heterologous P-fimbriae.
    Author: Kaack MB, Pere A, Korhonen TK, Svenson SB, Roberts JA.
    Journal: Pediatr Nephrol; 1989 Oct; 3(4):386-90. PubMed ID: 2577146.
    Abstract:
    To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with fimbriae purified from either Escherichia coli strain ER2 or strain JR1. The vaccinated animals showed elevated antibody titers to P-fimbriae from each of the E. coli strains used, suggesting cross-reactivity as was expected from the results of immunoprecipitation of the fimbriae. Enzyme-linked immunosorbent assay inhibition by heterologous P-fimbriae proved this to be true immunologic cross-reactivity.
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