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  • Title: Treatment of neuroleptic-induced akathisia with propranolol: a controlled replication study.
    Author: Kramer MS, Gorkin R, DiJohnson C.
    Journal: Hillside J Clin Psychiatry; 1989; 11(2):107-19. PubMed ID: 2577308.
    Abstract:
    Twelve DSM-IIIR diagnosed schizophrenics, with neuroleptic-induced akathisia (NIA), were treated with either propranolol or matched placebo for two days, followed by a treatment crossover phase for five more days. Raters and patients were "blind" to treatment. This study shows that 120 mg of propranolol a day is more effective than placebo in reducing akathisia, and that propranolol's antiakathisic effect may require several days of treatment.
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