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  • Title: TGF-β signal transduction pathways and osteoarthritis.
    Author: Zhai G, Doré J, Rahman P.
    Journal: Rheumatol Int; 2015 Aug; 35(8):1283-92. PubMed ID: 25773660.
    Abstract:
    Osteoarthritis (OA) is the most common form of arthritis, resulting in substantial disability and economic burden worldwide. While its exact pathogenesis remains elusive, both in vitro and human population-based studies have merged to support the hypothesis that TGF-β/BMP-mediated signalling pathways play a role in the development of OA. Unraveling the TGF-β/BMP-mediated mechanism(s) in OA has great potential in identifying novel targets and developing new drugs for OA treatment. This review summarizes both in vitro and in vivo evidence of TGF-β/BMP-mediated signal transduction pathways in OA and discusses the future research direction in this regard.
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