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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Psoriatic Nail Changes Are Associated With Clinical Outcomes in Psoriatic Arthritis.
    Author: Sandre MK, Rohekar S, Guenther L.
    Journal: J Cutan Med Surg; 2015; 19(4):367-76. PubMed ID: 25775610.
    Abstract:
    BACKGROUND: Nail changes are common in psoriatic arthritis (PsA), with varying relationships existing between skin, nail, and joint disease. OBJECTIVE: To further characterize relationships between nail changes, psoriasis, and joint involvement in PsA patients. METHODS: One hundred eighty-eight PsA patients had skin, fingernail, and rheumatological assessments completed. Hand and fingernail photographs were taken and reviewed by a dermatologist. RESULTS: Higher swollen joint counts were associated with distal interphalangeal (DIP)/periungual psoriasis (P=.001), more splinter hemorrhages (P=.006), and any nail bed change (P=.03). Higher tender joint counts were associated with rough onychorrhexis (P<.001), DIP/periungual psoriasis (P=.03), red lunula (P=.001), nail crumbling (P=.046), any nail matrix (P=.03), and nail bed change (P=.03). Joint involvement was associated with same-digit nail changes; strongest association was swollen or tender DIP with subungual hyperkeratosis, odds ratio=26.6 (95% CI, 5.1-139.1). CONCLUSION: The DIP/periungual psoriasis and specific nail changes were associated with higher joint counts and certain nail changes with same-digit joint involvement.
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