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  • Title: Scleroglucan sustained-release oral preparations. Part I. In vitro experiments.
    Author: Touitou E, Alhaique F, Riccieri FM, Riccioni G, Santucci E.
    Journal: Drug Des Deliv; 1989 Dec; 5(2):141-8. PubMed ID: 2577984.
    Abstract:
    Experiments performed in vitro with tablets and capsules indicate that the fungal polysaccharide scleroglucan is suitable for the formulation of sustained-release, oral dosage forms. Delivery of model drugs from the non-disintegrating matrix was studied in solutions buffered at different pH values. The effect on drug release of drug concentration, the physico-chemical properties of the drug, and the compression force used in the preparation of the matrix are reported, and the possible mechanisms of release are discussed.
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