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  • Title: Conformational changes of cytochromes P-450cam and P-450lin induced by high pressure.
    Author: Hui Bon Hoa G, Di Primo C, Dondaine I, Sligar SG, Gunsalus IC, Douzou P.
    Journal: Biochemistry; 1989 Jan 24; 28(2):651-6. PubMed ID: 2578028.
    Abstract:
    Absorbance and fluorescence spectra of bacterial cytochrome P-450cam and cytochrome P-450lin have been studied as a function of pressure. These pressure-induced spectral perturbations fall into two categories, which are interpreted as resulting from denaturation domains and are discussed in terms of protein structural dynamics. The results presented herein support a view that these two bacterial cytochromes have large structural differences and suggest a picture in which the gellike cortex of each protein may play an essential role in stability and function.
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