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  • Title: Standardization of allergenic extracts of Aspergillus fumigatus. Liberation of IgE-binding components during cultivation.
    Author: Kauffman HF, van der Heide S, van der Laan S, Hovenga H, Beaumont F, de Vries K.
    Journal: Int Arch Allergy Appl Immunol; 1985; 76(2):168-73. PubMed ID: 2578438.
    Abstract:
    During cultivation of Aspergillus fumigatus a rapid liberation of IgE-binding components was found reaching maximum values during the logarithmic phase of growth (phase I). After a fall in IgE-binding titers during phase II, appearance of additional IgE-binding components was noted during the period of lysis of the microorganism (phase III). These latter allergenic components are different from the phase I IgE-binding components, as was shown by crossed-inhibition studies. The number of precipitating antigenic components was not related with the corresponding IgE-binding titers and showed an increase during all phases of growth. The rapid changes in both IgE- and IgG-binding properties and the discrepancies between precipitating properties and IgE binding are discussed in relation to standardization and quality control of aspergillus extracts.
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