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  • Title: Distribution of keratin proteins in neoplastic and tumorlike lesions of squamous epithelium. An immunohistochemical study.
    Author: Mori M, Nakai M, Hyun KH, Noda Y, Kawamura K.
    Journal: Oral Surg Oral Med Oral Pathol; 1985 Jan; 59(1):63-9. PubMed ID: 2579363.
    Abstract:
    Seventy-six cases of tumorlike and neoplastic lesions from epidermis and oral epithelium were analyzed by a histochemical technique for the demonstration of keratin. Formalin-fixed paraffin sections were reacted with rabbit antihuman keratin antiserum (dilution of 1:40). The types of distribution of keratin in cells of lesions were classified into five categories: (1) regional, as found in normal squamous epithelia and benign hyperkeratinized lesions, and papilloma, and keratinized squamous cell carcinoma; (2) total, as seen in intensely keratinized lesions, such as verruca vulgaris and highly keratinized squamous cell carcinoma; (3) negative, as displayed by basal cell carcinoma; (4) scattered, as in the most poorly differentiated squamous cell carcinomas; and (5) mixed cellular, as found in both poorly and moderately differentiated squamous cell carcinomas.
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