These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: beta-Adrenergic induced K+ current in Xenopus oocytes: role of cAMP, inhibition by muscarinic agents. Author: Van Renterghem C, Renit-Soria J, Stinnakre J. Journal: Proc R Soc Lond B Biol Sci; 1985 Jan 22; 223(1232):389-402. PubMed ID: 2579401. Abstract: The K+ current induced by isoprenaline acting on beta-adrenergic receptors in Xenopus laevis has been studied in oocytes still surrounded by their follicular cells and inner ovarian epithelium. Forskolin, an adenylate cyclase activator, induced a similar K+ current and when used at subliminal concentration it potentiated the current induced by isoprenaline. Inhibition of phosphodiesterase by methylisobutylxanthine also enhanced the response to isoprenaline. 8-Br-cAMP, a permeant analogue of cAMP also produced a K+ current. Acetylcholine produced a long lasting inhibition of the isoprenaline current. This inhibition was not seen in the presence of atropine. It is concluded that the K+ current induced by the activation of beta-adrenergic receptors in the oocyte is mediated by an intracellular rise of cAMP.[Abstract] [Full Text] [Related] [New Search]