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Title: Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells. Author: Ishiuchi K, Kosuge Y, Hamagami H, Ozaki M, Ishige K, Ito Y, Kitanaka S. Journal: J Nat Med; 2015 Jul; 69(3):421-6. PubMed ID: 25794817. Abstract: Effususol A (1), a new 9,10-dihydrophenanthrene, has been isolated from the medullae of Juncus effusus along with ten known compounds, effusol (2), dehydroeffusol (3), juncusol (4), dehydrojuncusol (5), juncuenin B (6), dehydrojuncuenin B (7), juncuenin D (8), luteolin (9), luteolin 5-methyl ether (10), and 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (11). The structure of 1 was elucidated on the basis of spectroscopic data. 2, 4, 6, 7, and 8 have induced caspase-3-mediated cytotoxicity in HT22 cells.[Abstract] [Full Text] [Related] [New Search]