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  • Title: Nickel-catalyzed regio- and enantioselective aminolysis of 3,4-epoxy alcohols.
    Author: Wang C, Yamamoto H.
    Journal: J Am Chem Soc; 2015 Apr 08; 137(13):4308-11. PubMed ID: 25798573.
    Abstract:
    The first catalytic regio- and enantioselective aminolysis of 3,4-epoxy alcohols has been accomplished. Under the catalysis of Ni(ClO4)2·6H2O, the C4 selective ring opening of various 3,4-epoxy alcohols proceeded in a stereospecific manner with high regioselectivities. Furthermore, with the Ni-BINAM catalytic system the enantioselective ring opening of 3,4-epoxy alcohols furnished various γ-hydroxy-δ-amino alcohols as products with complete regiocontrol and high enantioselectivities (up to 94% ee).
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