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  • Title: Soya Saponins Induce Enteritis in Atlantic Salmon (Salmo salar L.).
    Author: Krogdahl Å, Gajardo K, Kortner TM, Penn M, Gu M, Berge GM, Bakke AM.
    Journal: J Agric Food Chem; 2015 Apr 22; 63(15):3887-902. PubMed ID: 25798699.
    Abstract:
    Soybean meal-induced enteritis (SBMIE) is a well-described condition in the distal intestine of salmonids, and saponins have been implicated as the causal agent. However, the question remains whether saponins alone cause SBMIE. Moreover, the dose-response relationship has not been described. In a 10 week feeding trial with Atlantic salmon, a highly purified (95%) soya saponin preparation was supplemented (0, 2, 4, 6, or 10 g/kg) to two basal diets, one containing fishmeal as the major protein source (FM) and the other 25% lupin meal (LP). Saponins caused dose-dependent increases in the severity of inflammation independent of the basal diet, with concomitant alterations in digestive functions and immunological marker expression. Thus, saponins induced inflammation whether the diet contained other legume components or not. However, responses were often the same or stronger in fish fed the corresponding saponin-supplemented LP diets despite lower saponin exposure, suggesting potentiation by other legume component(s).
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