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  • Title: Acute-phase response of plasma protein synthesis during experimental inflammation in neonatal rats.
    Author: Thomas T, Schreiber G.
    Journal: Inflammation; 1985 Mar; 9(1):1-7. PubMed ID: 2579907.
    Abstract:
    The pattern of plasma protein concentrations in neonatal rats differs characteristically from that in adult animals. Immediately after birth, the concentration of alpha 2-macroglobulin is about 200 times higher, that of major acute-phase alpha 1-protein the same, and that of alpha 1-acid glycoprotein, another acute phase protein, is considerably lower, compared with the values observed in healthy adults. The concentration of prealbumin, a negative acute-phase protein, remains low in the immediate postnatal period, but increases at a time when concentrations of both thyroxine and corticosterone increase. At this time, there is also a distinct increase in the concentration of alpha 1-acid glycoprotein. Despite the differences in concentration of plasma proteins in the adult rat and the neonate, the neonatal liver has the capability to respond to an acute inflammation with a coordinated change in the synthesis rates of plasma proteins similar to that observed in adult animals.
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