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  • Title: Phosphine-catalyzed highly enantioselective [3 + 3] cycloaddition of Morita-Baylis-Hillman carbonates with C,N-cyclic azomethine imines.
    Author: Zhang L, Liu H, Qiao G, Hou Z, Liu Y, Xiao Y, Guo H.
    Journal: J Am Chem Soc; 2015 Apr 08; 137(13):4316-9. PubMed ID: 25799312.
    Abstract:
    The first phosphine-catalyzed highly enantioselective [3 + 3] cycloaddition of Morita-Baylis-Hillman carbonates with C,N-cyclic azomethine imines is described. Using a spirocyclic chiral phosphine as the catalyst, a novel class of pharmaceutically interesting 4,6,7,11b-tetrahydro-1H-pyridazino[6,1-a]iso-quinoline derivatives were obtained in high yields with good to excellent diastereoselectivities and extremely excellent enantioselectivities (98->99% ee).
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