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  • Title: [Biosynthesis of nucleic acids and proteins in different time periods of development in experimental myocarditis].
    Author: Paskevich IF, Denisov VM, Rukavishnikova SM, Pakhomov VI, Kalimanov VG.
    Journal: Vopr Med Khim; 1985; 31(1):93-6. PubMed ID: 2580390.
    Abstract:
    Biosynthesis of DNA, RNA and protein was studied in rat myocardium within 1, 3, 5, 7, 14, 21 and 28 days after administration of adrenaline toxic doses (300 mg/100 g of body mass). Synthesis of DNA was activated within 1-7 days, of total proteins--within 1-14 days, of RNA--within 1-"1 days, of action and myosin in myocardium--within 3-21 days. All the patterns studied were normalized within the subsequent periods (21-28 days) although they exceeded the control values. These data and morphological assays suggest that restoration processes were activated due to regeneration of the impaired cardiomyocytes or to proliferation of fibroblasts.
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