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  • Title: Synthesis and biological evaluation of C-13' substituted 7'-homo-anhydrovinblastine derivatives.
    Author: Gherbovet O, La Spisa F, Thoret S, Alvarez MCG, Levaique H, Bignon J, Roussi F.
    Journal: Bioorg Med Chem Lett; 2015 Apr 15; 25(8):1771-1773. PubMed ID: 25804719.
    Abstract:
    Recent publications highlighted that vinca derivatives either functionalized on C-12' or enlarged on cycle C' could be more cytotoxic than vinblastine or vinorelbine, both used in anti-cancer therapy. By combining these two results, nine new 7'-homo-anhydrovinblastine derivatives functionalized on C-13' were elaborated. The synthesis of key intermediates, their one-step transformation into final products in mild conditions and their biological activities are presented.
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