These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Stimulation and inhibition of secretion by phorbol myristate acetate in different cell types.
    Author: Blackwell GJ, Bonser RW, Dawson J, Garland LG.
    Journal: Biochem Biophys Res Commun; 1985 Mar 29; 127(3):950-5. PubMed ID: 2580526.
    Abstract:
    In washed human platelets and in HL60 granulocytes phorbol myristate acetate (PMA, 1-2000nM) synergised with threshold concentrations of secretogogues to induce a sustained maximum secretory response. Likewise, superoxide production from HL60 cells maintained a maximal response at PMA concentrations between 30-300nM. At concentrations up to 10nM PMA also augmented calcium ionophore, A23187, stimulated histamine release from rat peritoneal mast cells. However, in the mast cell PMA concentrations above 10nM reduced maximum histamine release in a dose-dependent manner.
    [Abstract] [Full Text] [Related] [New Search]