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  • Title: Malignancy does not dictate the hypercoagulable state following liver resection.
    Author: Gordon N, Riha G, Billingsley K, Schreiber M.
    Journal: Am J Surg; 2015 May; 209(5):870-4. PubMed ID: 25805455.
    Abstract:
    BACKGROUND: A hypercoagulable state following intra-abdominal malignant resections has been reported. Whether this is because of the operation or the malignancy, a known cause of hypercoagulability, remains unclear. We determined if malignancy status affected the coagulation profile following liver resection by assessing perioperative thromboelastogram (TEG) values. METHODS: Retrospective review of prospectively collected TEG values in patients who received a liver resection was conducted. Values among patients with benign or malignant disease were compared. RESULTS: Fourteen and 63 patients were resected for benign and malignant disease, respectively. No significant differences in TEG values existed between the groups. Combining the groups, patients developed a relative hypercoagulable state postoperatively with decreased R-times (P < .05), although median values remained within the normal range. CONCLUSION: Following liver resection, no differences in TEG values existed between patients with benign and malignant disease; the relative hypercoagulable state is more likely driven by postoperative coagulopathy rather than the malignancy status of the patient.
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