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  • Title: [Blockers of the uncoupling action of caffeine on the Ca2+-transport function of sarcoplasmic reticulum membranes].
    Author: Ritov VB.
    Journal: Biull Eksp Biol Med; 1985 Apr; 99(4):445-8. PubMed ID: 2580576.
    Abstract:
    The influence of caffeine on the efficiency of Ca2+ transport in the presence of oxalate by different fractions of sarcoplasmic reticulum (SR) membranes from rabbit skeletal muscle was studied. It was shown that caffeine (5 mM) decreases 4-fold the value of the Ca/ATP ratio in terminal cisterns of the SR without having any appreciable influence on the efficiency of Ca2+ transport by the light fraction of the SR. The uncoupling effect of caffeine is completely blocked by ruthenium red and by the local anesthetics, tetracaine, procaine, and benzocaine.
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