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  • Title: Genital melanocytic naevus on lichen sclerosus: an uncommon occurrence and a management proposal.
    Author: Neri I, Dika E, Fanti PA, Misciali C, Patrizi A.
    Journal: J Eur Acad Dermatol Venereol; 2016 May; 30(5):794-7. PubMed ID: 25808039.
    Abstract:
    BACKGROUND: Melanocytic naevi located in special sites, such as the vulvar mucosa might present peculiar clinical and dermatoscopic features. OBJECTIVES: We describe a management proposal of a genital naevus associated with inflammatory disorders that aims to facilitate the clinical and pathologic diagnosis. METHODS: Videodermoscopy of a genital naevus associated with lichen sclerosus of an 8-year-old girl, was carried out before and 2 months after treatment with topical steroids. An excisional biopsy and immunohistochemical studies with HMB-45, MART -1 and molecular studies with p 16 staining were performed. RESULTS: The features of the melanocytic lesion associated with lichen sclerosus were troublesome on the basis of clinical and videodermoscopic evaluation. Histopathologic and immunohistochemical examination performed after topical treatment, showed a compound melanocytic naevus with an underlying inflammation consistent with lichen sclerosus. CONCLUSIONS: The evaluation of genital naevi should take into account the presence of inflammatory disorders, not uncommon in such location. Treatment of the latter and short follow-up of the patients, can avoid over-diagnosis of malignancies and extensive surgical procedures.
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