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  • Title: Total synthesis of the tetracyclic indole alkaloid ht-13-B.
    Author: Zhang Y, Hubbard JW, Akhmedov NG, Petersen JL, Söderberg BC.
    Journal: J Org Chem; 2015 May 01; 80(9):4783-90. PubMed ID: 25816174.
    Abstract:
    An expedient synthesis corroborating the proposed structure of the tetracyclic indole alkaloid ht-13-B is presented. Key synthetic steps include acyliminium ion allylation, a Mitsunobu reaction, a palladium-catalyzed Stille-Kelly cross coupling reaction, and a carbon monoxide-mediated palladium-catalyzed reductive N-heterocyclization. The chiral centers are ultimately derived from commercially available trans-4-hydroxy-l-proline.
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