These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Comparative analysis of integrated (99m)Tc-MIBI-SPECT/localizable CT and integrated ¹⁸F-FDG-PET/CT for differential diagnosis of solitary pulmonary nodules].
    Author: Deng Z, Li G, Xiang X, Jia L, Liu C, Chen T, Liu C.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2015 Mar; 35(3):422-6. PubMed ID: 25818793.
    Abstract:
    OBJECTIVE: To compare the diagnostic value of ⁹⁹Tc(m)-MIBI SPECT/localizable CT and ¹⁸FDG-PET/CT in patients with indeterminate solitary pulmonary nodules (SPNs) and assess the feasibility of using ⁹⁹Tc(m)-MIBI SPECT/localizable CT as an alternative when ¹⁸FDG-PET/CT is not available. METHODS: Thirty-nine patients with indeterminate SPNs were examined by ⁹⁹Tc(m)-MIBI SPECT/localizable CT, and another 46 patients by ¹⁸FDG-PET/CT. The findings of the two modalities were analyzed qualitatively and semiquantitatively to assess their efficacy for a definitive diagnosis of SNPs. RESULTS: Of the 39 patients examined by ⁹⁹Tc(m)-MIBI SPECT/localizable CT, 13 were identified to have malignant SPNs and 26 had benign SPNs; the diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of the examination were 92.31% (12/13), 88.46% (23/26), 89.74% (35/39), 80% (12/15) and 95.83% (23/24), respectively. Of the 46 patients receiving ¹⁸FDG-PET/CT examination, 29 malignant cases and 17 benign cases were identified with a diagnostic sensitivity, specificity, accuracy, PPV and NPV of 96.55% (28/29), 76.47% (13/17), 89.13% (41/46), 87.50% (28/32) and 92.86% (13/14), respectively. The two modalities showed no significant differences in the diagnostic sensitivity (χ² =0.356, P=0.55), specificity (χ² =1.084, P=0.298), accuracy (χ² = 0.008, P=0.927), PPV (χ² = 0.453, P=0.501) or NPV (χ² =0.157, P=0.692). The ROC curve showed that with the early uptake ratio (EUR) of ⁹⁹Tc(m)-MIBI ≥ 1.474 and ≥ 1.38 as the cutoff values, the sensitivity of ⁹⁹Tc(m)-MIBI SPECT/localizable CT was both 100% and the specificity both 76.90%; with the maximum standard uptake value (SUVmax) of ¹⁸FDG ≥ 2.40 as the cutoff value, the sensitivity of ¹⁸FDG-PET/CT was 96.60% and the specificity was 76.50%, showing no significant differences between the two modalities in the diagnostic efficacy. CONCLUSION: ⁹⁹Tc(m)-MIBI-SPECT/localizable CT may be a useful and practical modality for early diagnosis of SNPs for patients with a medium or low income in small and medium-sized cities.
    [Abstract] [Full Text] [Related] [New Search]