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  • Title: Reactive oxygen species-mediated bacterial killing by B lymphocytes.
    Author: Kovács I, Horváth M, Lányi Á, Petheő GL, Geiszt M.
    Journal: J Leukoc Biol; 2015 Jun; 97(6):1133-7. PubMed ID: 25821233.
    Abstract:
    Regulated production of ROS is mainly attributed to Nox family enzymes. In neutrophil granulocytes and macrophages, Nox2 has a crucial role in bacterial killing, and the absence of phagocytic ROS production leads to the development of CGD. Expression of Nox2 was also described in B lymphocytes, where the role of the enzyme is still poorly understood. Here, we show that peritoneal B cells, which were shown recently to possess phagocytic activity, have a high capacity to produce ROS in a Nox2-dependent manner. In phagocytosing B cells, intense intraphagosomal ROS production is detected. Finally, by studying 2 animal models of CGD, we demonstrate that phagocyte oxidase-deficient B cells have a reduced capacity to kill bacteria. Our observations extend the number of immune cell types that produce ROS to kill pathogens.
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