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  • Title: Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery.
    Author: Druzhenko T, Denisenko O, Kheylik Y, Zozulya S, Shishkina SS, Tolmachev A, Mykhailiuk PK.
    Journal: Org Lett; 2015 Apr 17; 17(8):1922-5. PubMed ID: 25823962.
    Abstract:
    A set of novel SO2-containing azabicyclo[3.n.1]alkanes has been synthesized by the double-Mannich annulation of of the corresponding monocyclic S-ketones. These compounds have been rationally designed as 3D-shaped, conformationally restricted SO2-containing building blocks for drug discovery.
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