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  • Title: Synthesis of each enantiomer of rocaglamide by means of a palladium(0)-catalyzed Nazarov-type cyclization.
    Author: Zhou Z, Tius MA.
    Journal: Angew Chem Int Ed Engl; 2015 May 11; 54(20):6037-40. PubMed ID: 25824525.
    Abstract:
    A recently reported Pd(0)-catalyzed asymmetric Nazarov-type cyclization has been successfully applied in the key step of the first catalytic asymmetric total synthesis of (-)-rocaglamide (natural) and (+)-rocaglamide. The stereochemistry at the C3 position that controls the stereochemistry of all other stereocenters is determined in the cyclization step. This versatile and modular synthesis proceeds from simple reagents.
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