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  • Title: Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells.
    Author: Lee D, Kim KH, Moon SW, Lee H, Kang KS, Lee JW.
    Journal: Bioorg Med Chem Lett; 2015 May 01; 25(9):1929-32. PubMed ID: 25824663.
    Abstract:
    Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.
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