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  • Title: An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C(sp(3))-H bond insertion.
    Author: Shen MH, Pan YP, Jia ZH, Ren XT, Zhang P, Xu HD.
    Journal: Org Biomol Chem; 2015 May 07; 13(17):4851-4. PubMed ID: 25826185.
    Abstract:
    A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation.
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