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  • Title: Pulse wave velocity distribution in a cohort study: from arterial stiffness to early vascular aging.
    Author: Cunha PG, Cotter J, Oliveira P, Vila I, Boutouyrie P, Laurent S, Nilsson PM, Scuteri A, Sousa N.
    Journal: J Hypertens; 2015 Jul; 33(7):1438-45. PubMed ID: 25827429.
    Abstract:
    BACKGROUND: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. METHOD: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from northern Portugal, and used as a marker of early vascular aging (EVA). Of the 3038 individuals enrolled, 2542 completed the evaluation. RESULTS: Mean PWV value for the entire population was 8.4  m/s (men: 8.6  m/s; women: 8.2  m/s; P < 0.02). The individuals were classified with EVA if their PWV was at least 97.5th percentile of z-score for mean PWV values adjusted for age (using normal European reference values as comparators). The overall prevalence of EVA was 12.5%; 26.1% of individuals below 30 years presented this feature and 40.2% of individuals in that same age strata were placed above the 90th percentile of PWV; and 18.7% of the population exhibited PWV values above 10  m/s, with male predominance (17.2% of men aged 40-49 years had PWV > 10  m/s). Logistic regression models indicated gender differences concerning the risk of developing large artery damage, with women having the same odds of PWV above 10  m/s 10 years later than men. CONCLUSION: The population PWV values were higher than expected in a low cardiovascular risk area (Portugal). High prevalence rates of EVA and noteworthy large artery damage in young ages were found.
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