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  • Title: [Abnormality of T cell subsets in patients with idiopathic thrombocytopenic purpura].
    Author: Song LJ, Yu JR, Ma SJ.
    Journal: Zhonghua Nei Ke Za Zhi; 1989 Jun; 28(6):364-7, 382-3. PubMed ID: 2582916.
    Abstract:
    Fifty patients with idiopathic thrombocytopenic purpura (ITP) and 50 normal controls were studied for T cell subsets using OKT monoclonal antibodies. These patients were found to have lower proportions of OKT4+ subset and higher proportions of OKT8+ ratio than the healthy controls. The perturbation was more severe in patients with active disease. A significant increase of OKT 4+8+ double-labelled cells deduced by a subtraction method was also observed in the peripheral blood of patients and an inverse correlation was demonstrated between the proportions of OKT4+8+ subset and the platelet counts. Furthermore, a positive correlation between the proportions of OKT4-8+ subset and the platelet counts was also found in patients with active ITP. These data suggest that abnormalities of T cell subsets in the peripheral blood may play an important role in the pathogenesis of ITP.
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