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  • Title: Severe antiphospholipid syndrome and cardiac surgery: Perioperative management.
    Author: Mishra PK, Khazi FM, Yiu P, Billing JS.
    Journal: Asian Cardiovasc Thorac Ann; 2016 Jun; 24(5):473-6. PubMed ID: 25829458.
    Abstract:
    Antiphospholipid syndrome is an antiphospholipid antibody-mediated prothrombotic state leading to arterial and venous thrombosis. This condition alters routine in-vitro coagulation tests, making results unreliable. Antiphospholipid syndrome patients requiring cardiac surgery with cardiopulmonary bypass present a unique challenge in perioperative anticoagulation management. We describe 3 patients with antiphospholipid syndrome who had successful heart valve surgery at our institution. We have devised an institutional protocol for antiphospholipid syndrome patients, and all 3 patients were managed according to this protocol. An algorithm-based approach is recommended because it improves team work, optimizes treatment, and improves patient outcome.
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